Susan O'Brien Selected Research

Dexamethasone (Maxidex)

7/2023	Impact of triple intrathecal prophylaxis in acute lymphoblastic leukemia adults receiving HyperCVAD: A COVID-19 practice change.
5/2015	Final report of a phase II study of imatinib mesylate with hyper-CVAD for the front-line treatment of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.
2/2015	Phase II study of methotrexate, vincristine, pegylated-asparaginase, and dexamethasone (MOpAD) in patients with relapsed/refractory acute lymphoblastic leukemia.
10/2012	A randomized controlled trial of an intensive insulin regimen in patients with hyperglycemic acute lymphoblastic leukemia.
2/2011	Augmented hyper-CVAD based on dose-intensified vincristine, dexamethasone, and asparaginase in adult acute lymphoblastic leukemia salvage therapy.
10/2010	Anthracycline dose intensification in adult acute lymphoblastic leukemia: lack of benefit in the context of the fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone regimen.
8/2010	Chemoimmunotherapy with a modified hyper-CVAD and rituximab regimen improves outcome in de novo Philadelphia chromosome-negative precursor B-lineage acute lymphoblastic leukemia.
12/2009	Phase 1 multicenter study of vincristine sulfate liposomes injection and dexamethasone in adults with relapsed or refractory acute lymphoblastic leukemia.
5/2009	Adults with acute lymphoblastic leukemia and translocation (1;19) abnormality have a favorable outcome with hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with methotrexate and high-dose cytarabine chemotherapy.
1/2009	Therapy-related acute myelogenous leukemia and myelodysplastic syndrome in patients with acute lymphoblastic leukemia treated with the hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone regimens.

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Susan O'Brien Research Topics

Disease

134	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 04/2024 - 02/2002
123	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2020 - 03/2002
83	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 11/2023 - 01/2002
65	Neoplasms (Cancer) 02/2024 - 02/2002
64	Philadelphia Chromosome 01/2023 - 04/2002
55	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 09/2017 - 01/2002
47	Leukemia 12/2022 - 03/2002
40	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 06/2015 - 01/2002
22	Infections 01/2023 - 01/2002
19	Residual Neoplasm 10/2022 - 01/2003
17	Blast Crisis (Blast Phase) 01/2020 - 05/2002
16	Lymphoma (Lymphomas) 01/2019 - 02/2002
16	Hematologic Neoplasms (Hematological Malignancy) 11/2018 - 01/2002
15	Disease Progression 01/2022 - 06/2005
14	Diarrhea 01/2023 - 08/2002
12	Acute Promyelocytic Leukemia 01/2017 - 06/2002
10	Hypertension (High Blood Pressure) 01/2023 - 11/2015
10	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 01/2022 - 02/2002
10	Anemia 01/2018 - 03/2002
9	Primary Myelofibrosis (Myelosclerosis) 02/2017 - 09/2002
9	Chronic Myelomonocytic Leukemia (Leukemia, Chronic Myelomonocytic) 04/2014 - 06/2003
8	Atrial Fibrillation 01/2023 - 01/2016
8	Hemorrhage 01/2023 - 06/2009
8	Lymphocytosis 01/2020 - 09/2011
8	Thrombocytopenia (Thrombopenia) 01/2019 - 09/2002
8	Pathologic Complete Response 12/2018 - 06/2002
8	Neutropenia 11/2018 - 06/2003
7	Nausea 09/2018 - 12/2003
7	Cytopenia 03/2017 - 11/2007
7	Chromosome Aberrations (Chromosome Abnormalities) 07/2014 - 08/2002
6	Hairy Cell Leukemia 05/2024 - 09/2002
6	B-Cell Lymphoma (Lymphoma, B Cell) 02/2024 - 02/2002
6	Exanthema (Rash) 01/2023 - 06/2009
6	Non-Hodgkin Lymphoma (Lymphosarcoma) 11/2019 - 01/2014
5	Tumor Lysis Syndrome 02/2024 - 03/2007
5	Fatigue 12/2018 - 06/2003
5	Leukocytosis (Pleocytosis) 01/2017 - 12/2003
5	Trisomy (Trisomies) 07/2015 - 08/2002
5	Burkitt Lymphoma (Burkitt's Lymphoma) 06/2015 - 03/2002
5	Splenomegaly 10/2011 - 03/2002
5	Myeloproliferative Disorders (Myeloproliferative Disorder) 06/2008 - 09/2002
4	Pancreatitis 01/2023 - 11/2015
4	Myocardial Infarction 01/2023 - 10/2007
4	Second Primary Neoplasms (Neoplasms, Second) 05/2019 - 03/2007
4	Pneumonia (Pneumonitis) 01/2019 - 01/2016

Drug/Important Bio-Agent (IBA)

88	Imatinib Mesylate (Gleevec)FDA Link 01/2018 - 05/2002
51	ibrutinibIBA 01/2023 - 02/2012
49	Tyrosine Kinase InhibitorsIBA 01/2023 - 09/2003
43	Rituximab (Mabthera)FDA Link 05/2024 - 02/2002
36	Cytarabine (Cytosar-U)FDA LinkGeneric 07/2023 - 03/2002
33	fludarabineIBA 12/2021 - 10/2002
32	Monoclonal AntibodiesIBA 11/2019 - 02/2002
29	Cyclophosphamide (Cytoxan)FDA LinkGeneric 07/2023 - 01/2002
23	Agammaglobulinaemia Tyrosine KinaseIBA 01/2022 - 02/2012
23	Dasatinib (BMS 354825)FDA Link 01/2020 - 06/2006
19	Vincristine (Oncovin)FDA LinkGeneric 07/2023 - 01/2002
18	Inotuzumab OzogamicinIBA 01/2023 - 06/2013
18	Proteins (Proteins, Gene)FDA Link 11/2019 - 03/2002
15	nilotinib FDA Link 01/2020 - 06/2006
15	Alemtuzumab (Campath)FDA Link 08/2011 - 05/2003
14	Dexamethasone (Maxidex)FDA LinkGeneric 07/2023 - 01/2002
14	Phosphotransferases (Kinase)IBA 06/2018 - 12/2003
13	Interferon-alpha (Interferon Alfa)IBA 06/2012 - 04/2002
12	Doxorubicin (Adriamycin)FDA LinkGeneric 07/2023 - 01/2002
12	InterferonsIBA 06/2012 - 06/2003
11	Idarubicin (4 Demethoxydaunorubicin)FDA LinkGeneric 01/2017 - 06/2002
10	Decitabine FDA Link 03/2015 - 08/2003
9	Transaminases (Aminotransferases)IBA 01/2023 - 04/2012
9	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2017 - 06/2002
8	BilirubinIBA 01/2023 - 04/2012
8	Gemtuzumab (Mylotarg)FDA Link 01/2017 - 01/2002
8	Clofarabine (Clolar)FDA Link 06/2014 - 03/2003
7	Messenger RNA (mRNA)IBA 12/2023 - 02/2007
7	ponatinibIBA 01/2023 - 04/2015
7	Hemoglobins (Hemoglobin)IBA 02/2014 - 04/2002
7	bcr-abl Fusion ProteinsIBA 01/2008 - 07/2002
6	venetoclaxIBA 02/2024 - 12/2015
6	Methotrexate (Mexate)FDA LinkGeneric 07/2023 - 03/2002
6	acalabrutinibIBA 01/2023 - 01/2016
6	idelalisibIBA 12/2020 - 09/2011
6	Arsenic Trioxide (Trisenox)FDA Link 01/2017 - 05/2003
6	LigandsIBA 07/2015 - 04/2003
6	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 06/2015 - 07/2008
6	NucleosidesIBA 06/2014 - 12/2003
6	Alkylating AgentsIBA 07/2009 - 01/2004
5	blinatumomabIBA 01/2023 - 10/2018
5	ofatumumab FDA Link 12/2018 - 10/2010
5	HomoharringtonineIBA 01/2017 - 04/2002
5	Biomarkers (Surrogate Marker)IBA 12/2015 - 02/2010
5	Erythropoietin FDA Link 11/2010 - 04/2002
5	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 02/2009 - 03/2002
5	TransferasesIBA 11/2007 - 03/2003
4	Cladribine FDA LinkGeneric 05/2024 - 01/2003
4	CreatinineIBA 10/2022 - 10/2007
4	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2018 - 09/2011

Therapy/Procedure

192	Therapeutics 04/2024 - 03/2002
61	Drug Therapy (Chemotherapy) 07/2023 - 01/2002
15	Salvage Therapy 01/2023 - 08/2005
13	Stem Cell Transplantation 01/2023 - 09/2002
4	Immunotherapy 12/2022 - 10/2009